Orasi's technology analyzes Magnetoencephalography (MEG) data, and is based on over five years of research and development at the University of Minnesota and the VA Medical Hospital. MEG is a technique that measures small magnetic signals produced by the electrical activity of the brain in real-time.
Using MEG data, Orasi compares patterns of a patient's brain electrical activity against libraries of similar data for healthy and diseased individuals. In 2007, Orasi secured an exclusive, world-wide license to the patents, copyrights, and data for this technology from the University of Minnesota.
Since inception we have analyzed data on more than 626 subjects with a variety of neurological diseases (Alzheimer's disease, schizophrenia, Sjogrens, multiple sclerosis, mild cognitive impairment, myofacial pain, normal healthy controls), collected from three US geographic locations (Denver, CO; Minneapolis, MN; Houston, TX). Subsequent in-house analysis of Alzheimer's diagnostic accuracy using our software technology achieves 96% sensitivity (% correct Alzheimer's) and 90% specificity (% correct non-Alzheimer's), based on 47 Alzheimer's subjects and 90 control (non-Alzheimer's) subjects (Fig 1.3). Comparatively, clinicians (including general practitioners and neurologists) on average achieve only 81% sensitivity and specificity after a longer period of diagnositic effort. Follow-up clinical validation studies will be required as part of the FDA review process for U.S. marketing.
Fig 1.3 Patterns of normal (non-Alzheimer's) brain function and Alzheimer's disease function as measured by the Orasi Synchronous Neural Interactions test.
Orasi offers a "software-as-a-service" product to physicians. First, physicians order a MEG scan (the process is similar to a physician ordering an MRI). Next, the MEG technician sends the patient's data to Orasi using a web-based interface. Then, Orasi interprets the results and sends a full report to the physician to use as an aid in diagnosis. The entire process will be fully automated, from the moment the MEG data is sent over the web to Orasi, to the moment the results arrive at the physician's office. (Fig 1.4)
Fig 1.4 How does it work?
Please note:
Orasi products have not been cleared by the U.S. Food and Drug Administration and are not for sale or distribution in the U.S..